STATEMENT OF NEED

Tumor lysis syndrome (TLS) is an oncological emergency that occurs when massive tumor lysis causes the rapid release of intracellular components into the bloodstream. Electrolyte imbalances characterized by hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia may be severe enough to cause acute renal failure, cardiac arrhythmias, seizures, and even death. Current advances in cancer therapies can increase the incidence of TLS; therefore, identification of patients at risk for TLS and prophylactic measures to prevent TLS are critically important to preventing morbidity and mortality. This manuscript reviews the pathophysiology of TLS, the identification of patients at risk of TLS and the appropriate prophylactic treatment, the signs and symptoms of TLS, and supportive care measures to optimize outcomes when TLS does occur.

TARGET AUDIENCE

Oncology nurses, nurse practitioners, clinical nurse specialists, and other health care professionals involved in the treatment of various tumor types

LEARNING OBJECTIVES

Upon completion of this activity, participants should be able to: 

• Distinguish the risk factors, signs and symptoms of clinical and laboratory tumor lysis syndrome
• Evaluate current and emerging options for the prophylaxis and treatment of patients with tumor lysis syndrome
• Implement supportive care best practices for patients with tumor lysis syndrome

Provided by

ACCREDITATION

i3 Health is accredited with distinction as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation.

A maximum of 1.0 contact hour may be earned by learners who successfully complete this NCPD activity.

Provider approved by the California Board of Registered Nursing, Provider Number 15824, for 1.0 contact hour.

ONCC RECERTIFICATION

The program content has been reviewed by the Oncology Nursing Certification Corporation (ONCC) and is acceptable for recertification points.

ONCC review is only for designating content to be used for recertification points and is not for NCPD accreditation. NCPD programs must be formally approved for contact hours by an acceptable accreditor/approver of NCPD to be used for recertification by ONCC. If the NCPD provider fails to obtain formal approval to award contact hours by an acceptable accrediting/approval body, no information related to ONCC recertification may be used in relation to the program. OCN®, CPHON®, CBCN®, AOCNP®, AOCNS®, and BMTCN® renewal candidates may apply 1 ILNA point toward:

• Early Post-Transplant Management and Education (BMTCN®)
• Oncologic Emergencies (OCN®, CPHON®, AOCNP®)
• Symptom Management
• Palliative Care, Supportive Care (OCN®, CPHON®, AOCNP®)

Please note that some of the course content applies to multiple content areas. The numerical value above indicates the maximum amount of points that can be claimed in each domain. The total amount of ILNA points claimed may not exceed the total amount of NCPD awarded from this course.

REQUIREMENTS FOR CREDIT

To claim your NCPD certificate for this activity, please complete the following steps:

1. Take the pretest
2. Read the monograph
3. Pass the posttest with a score of ≥80%
4. Complete the activity evaluation
5. Download your certificate of completion

TECHNOLOGY REQUIREMENTS FOR VIRTUAL CME | NCPD | CPE ACTIVITIES

For virtual (asynchronous, archived live, home study; synchronous webinars) CME/NCPD/CE activities, include access to system requirements:

• The Internet browser(s) supported and minimum versions of each required by the learner to complete the online activity.
• The minimum memory, storage, processor, and Internet speeds require by the learner to complete the online activity.

DISCLOSURE OF RELEVANT FINANCIAL INFORMATION WITH INELIGIBLE COMPANIES

i3 Health endorses the standards of the ANCC that require everyone in a position to control the content of a NCPD activity to disclose all financial relationships with ineligible companies that are related to the content of the NCPD activity. NCPD activities must be balanced, independent of commercial bias, and promote improvements or quality in health care. All recommendations involving clinical medicine must be based on evidence accepted within the medical profession. A conflict of interest is created when an individual has an opportunity to affect CME/NCPD content about products or services of a commercial interest with which he/she has a financial relationship, which therefore may bias their opinions and teaching. This may include receiving a salary, royalty, intellectual property rights, consulting fee, honoraria, stocks, or other financial benefits. i3 Health will identify, review, and mitigate all conflicts of interest that speakers, authors, or planners disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. i3 Health does not endorse any products or services. Relevant financial relationships exist between the following individuals and commercial interests:

• i3 Health staff members and the peer/content reviewer for this activity have no relevant financial relationships to disclose

i3 Health has mitigated all relevant financial relationships.

UNAPPROVED USE DISCLOSURE

i3 Health requires NCPD faculty to disclose to participants when products or procedures being discussed are off-label, unlabeled, experimental, and/or investigational (not FDA approved), as well as any limitations on the information that is presented, such as data that are preliminary or that represent ongoing research, interim analyses, and/or unsupported opinion. Faculty will not discuss information about pharmaceutical agents that is outside of FDA approved labeling. This information is intended solely for educational purposes and is not intended to promote off-label use of these medications. If you have questions, contact the medical affairs department of the manufacturer for the most recent prescribing information.

DISCLAIMER

The information provided in this NCPD activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

TECHNICAL/CREDIT QUERIES

Technical queries about this activity should be directed to support@i3health.com.